Invest in the Biology of How You Age
Clinician-prescribed longevity protocols targeting cellular energy, antioxidant defense, and mitochondrial health. Your independently licensed provider designs a personalized protocol based on your health profile and wellness goals.
The Science of Aging: And How to Support It
Aging is not a single event. It is a cascade of cellular changes, declining energy production, accumulating oxidative damage, and weakening repair mechanisms, that research suggests may begin decades before visible symptoms appear.
At the center of cellular aging is NAD+ (nicotinamide adenine dinucleotide), a coenzyme present in every living cell. NAD+ is essential for mitochondrial energy production and the activation of sirtuins, proteins involved in DNA repair and cellular stress response. Research published in the journal Age found that human NAD+ levels may decline by approximately 50% between ages 40 and 60, a trajectory that correlates with reduced cellular function.
Oxidative stress, the imbalance between free radical production and antioxidant defense, is one of the most widely studied mechanisms of biological aging. Glutathione, the body's most abundant intracellular antioxidant, plays a central role in neutralizing reactive oxygen species and supporting cellular detoxification. Published research has explored the relationship between age-related glutathione depletion and increased vulnerability to oxidative damage.
Mitochondrial dysfunction is another area of active longevity research. As mitochondria lose efficiency, cells produce less ATP and more damaging byproducts. Compounds such as methylene blue have been studied in preclinical models for their potential to support mitochondrial electron transport chain function, though human clinical data remains limited.
Cellular Energy Decline
NAD+ is required for mitochondrial ATP production and sirtuin activation. Research suggests that NAD+ levels decline significantly with age, correlating with reduced cellular energy output and impaired DNA repair capacity.
Massudi et al., Age, 2012Antioxidant Defense
Glutathione neutralizes reactive oxygen species and supports phase II detoxification pathways in the liver. Age-related depletion of glutathione has been explored as a contributing factor to oxidative stress and cellular vulnerability.
Sekhar et al., J Clin Endocrinol Metab, 2011Mitochondrial Support
Mitochondrial efficiency declines with age, reducing cellular energy and increasing oxidative byproducts. Methylene blue has been studied in preclinical models for its ability to act as an alternative electron carrier in the mitochondrial transport chain.
Wen et al., Free Radical Biology and Medicine, 2011Research suggests NAD+ levels may decline by approximately 50% between ages 40 and 60, coinciding with measurable changes in cellular energy production and repair capacity.
References
- Human skin NAD+ declines with age: observations from a cross-sectional study, 2012. Age(PMID 21935766).
- Glutathione synthesis is diminished in patients with uncontrolled diabetes and restored by dietary supplementation with cysteine and glycine, 2011. Journal of Clinical Endocrinology & Metabolism(PMID 21849523).
- Alternative mitochondrial electron transfer as a novel strategy for neuroprotection, 2011. Free Radical Biology and Medicine(PMID 21167935).
- Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults, 2018. Nature Communications(PMID 29184669).
- Glutathione deficiency is associated with impaired mitochondrial fuel oxidation and aging in humans, 2023. Journal of Clinical Investigation(PMID 36594464).
Choose your treatment
NAD+ Therapy
Cellular energy and repair at the molecular level
- Injection, nasal, or oral dropper
- Cellular energy support
- DNA repair and longevity
- Provider consultation included
Glutathione Injection
The master antioxidant
- Intramuscular injection
- Master antioxidant
- Immune support
- Detoxification support
Methylene Blue
Mitochondrial support and cognitive enhancement
- Oral administration
- Mitochondrial support
- Cognitive enhancement
- Neuroprotection research
B12 MIC Injection
Energy, metabolism, and fat burning support
- Lipotropic injection
- Energy and metabolism boost
- Fat utilization support
- B12 + MIC complex
Compounded medications are not FDA-approved. All medications require provider approval. Pricing includes provider consultation, medication, and shipping. Cancel anytime.
Invest in Your Longevity
A 4-minute assessment is the first step toward a personalized longevity protocol prescribed by a licensed clinician.
Licensed providers. State-licensed pharmacies. Free shipping.
Age on Your Terms
Vitality at every age
Mindful wellness practices
Staying active, staying sharp
Nutrition meets science
Investing in tomorrow
Images are for illustrative purposes only and do not represent actual patients or guaranteed results. Some images may be AI-generated or digitally enhanced.
Your Personalized Protocol
Complete Your Assessment
Answer a 4-minute online health questionnaire covering your medical history, current supplements, lifestyle, and longevity goals. No commitment and no payment required at this stage.
Provider Evaluation
An independently licensed clinician reviews your complete health profile and determines whether a longevity protocol is medically appropriate for your individual needs.
Personalized Protocol
If clinically appropriate, your provider prescribes a compounded longevity protocol tailored to your health profile. Your provider selects compounds, dosages, and delivery methods based on their professional medical judgment.
Delivered to Your Door
Your compounded medications are prepared by a state-licensed pharmacy and shipped directly to you in discreet packaging with free priority shipping. Ongoing provider oversight included.
Frequently Asked Questions
About Treatment
About the Process
Safety & Research
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Science-Backed Longevity, Prescribed for You
Complete a brief health assessment and a licensed provider will evaluate whether a longevity protocol is appropriate for your individual needs. No commitment required.
Research-backed compounds. Licensed clinicians. Free shipping.
Important Disclosures
The Prescriva platform is operated by Blue Oak Services LLC dba Prescriva, a management services organization (MSO). Blue Oak Services LLC dba Prescriva does not provide medical services, diagnoses, or prescriptions. All medical treatment, including prescribing decisions, is provided by independently licensed healthcare providers. The prescribing provider retains sole discretion over treatment decisions.
Individual results may vary and are not guaranteed. Results may be affected by individual adherence to the treatment plan, lifestyle factors, and the clinical recommendations of your prescribing provider. The information provided on this website is for educational purposes and does not constitute medical advice.
The medications offered through the Prescriva platform are compounded medications. Compounded medications are not FDA-approved. They are prepared by state-licensed compounding pharmacies. Compounded medications have not been evaluated by the FDA for safety, efficacy, or quality. These products are not the same as, equivalent to, or substitutes for FDA-approved medications.
All compounded medications are prepared by state-licensed compounding pharmacies that operate under applicable state and federal regulations. The compounding pharmacies used by Prescriva are independent entities and are not owned or operated by Blue Oak Services LLC dba Prescriva.
Images shown are for illustrative purposes only and may feature models or digitally created content. They do not represent actual patients or guaranteed results.
Testimonials and reviews reflect individual experiences and are not representative of all users. Individual results vary based on starting health, adherence to treatment, and lifestyle factors. No specific outcome is guaranteed. These statements have not been evaluated by the FDA.